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That gap is real, and it matters
GLP-1: Addresses Driven by obesogens environmental chemicals that act as pseudo-hormones, disrupting endocrine signaling
Interestingly the concentration of reduced forms of GPxs and Prxs depend on the concentration of other antioxidants and by increasing the concentration of one of the other antioxidants the concentrations of the reduced forms of GPxs and Prxs increase
For others, the drug improves the kind of test results doctors watch as early warning signs of disease (blood pressure, cholesterol, kidney markers), but the trials that would tell us whether the things we actually care about (heart attacks, strokes, kidney failure) also improve have not yet been reported